Francesco de Layolle (also spelled dell'Aiolle, dell'Aiuola, dell'Ajolle, dell'Aiolli), (March 4, 1492 – c. 1540) was an Italian composer and organist of the Renaissance. He was one of the first native Italian composers to write sacred music in the Franco-Flemish polyphonic style, combining it with the indigenous harmonic idioms of the Italian peninsula.